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Viagra and its side effects

The main API in Viagra is a sildenafil citrate, is an orally active drug discovered by Pfizer for the treatment of Male Erectile Dysfunction. Sildenafil is an act by a selective inhibitor of (cGMP)-specific phosphodiesterase type 5 (PDE5), and increasing NO(Nitric Oxide) action in corpus cavernosum.Viagra is an under Schedule H drug (that means to be sold at retail on the prescription of registered medical practitioner only)

Oral Bioavailability of Sildenafil is ~40% and mainly metabolized by the enzyme CYP3A4. Viagra dose recommended in a dose of 50 mg, if it’s not effective then increased in dose i.e. 100 mg before intercourse

NO(Nitric Oxide) is important to regulatory of pulmonary vascular resistances, PDE-5inhibits lower pulmonary atrial pressure. The Sildenafil is only PDE-5 inhibitors shown improve arterial oxygenation in pulmonary hypertension. Because of these the sildenafil/Viagra drug of choice for this condition.

A Side effect of Viagra is mainly due to PDE-5 inhibitor-related such as vasodilation, headache, nasal congestion, dizziness, flushing, fall in B.P.(Blood Pressure), loose motion, skin rashes, vomiting, abnormal vision.

The manufacture advises that sildenafil/Viagra is should not be used in patients with a hereditary retinal degenerative disease because of its weakly inhibits isoenzyme PDE-6 which is involved in photoreceptor transduction in the retina. As such, impairment of color vision, especially blue-green discrimination occurs in recipients. In few cases of sudden loss of vision due to nonarteritic ischemic point neuropathy (NAION) has been reported.

Viagra is contraindicated in Coronary heart disease & those patients taking Nitrate is increasing risk of potentially life threating hypotension

Also, caution is advised in some races which is suffering from sickle cell anemia, myeloma, and in leukemia.

Drug–Drug interactions with Viagra are Antifungal, Antibiotics, Antianginal (Nitrate), some anti-hypertensive medicine

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